GNB1L/GY2

Acts as a critical regulator of DNA damage response (DDR) signaling via specifically regulating phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.

Ubiquitous. Highly expressed in heart, liver, skeletal muscle, kidney, spleen, thymus and pancreas. Detected at low levels in lung, placenta and brain.

• Cytoplasm
• Nucleus
• Localizes mainly in cytosol and to a lesser extent in the nucleus.

GY2, KIAA1645, WDR14, FKSG1, GNB1L, Guanine nucleotide-binding protein subunit beta-like protein 1, G protein subunit beta-like protein 1, DGCRK3, WD repeat-containing protein 14, WD40 repeat-containing protein deleted in VCFS, WDVCF

• entrezGene:54584
• omim:610778
• swissprot:Q9BYB4

Proteins

35618Da