GNB1L
Function
Acts as a critical regulator of DNA damage response (DDR) signaling via specifically regulating phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.
Tissue Specificity
Ubiquitous. Highly expressed in heart, liver, skeletal muscle, kidney, spleen, thymus and pancreas. Detected at low levels in lung, placenta and brain.
Cellular localization
- Cytoplasm
- Nucleus
- Localizes mainly in cytosol and to a lesser extent in the nucleus.
Alternative names
GY2, KIAA1645, WDR14, FKSG1, GNB1L, Guanine nucleotide-binding protein subunit beta-like protein 1, G protein subunit beta-like protein 1, DGCRK3, WD repeat-containing protein 14, WD40 repeat-containing protein deleted in VCFS, WDVCF