GNL3
Domain
The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).
In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Function
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Sequence Similarities
Belongs to the TRAFAC class YlqF/YawG GTPase family.
Tissue Specificity
Increased levels in lung tissue in cancer patients.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
- Shuttles between the nucleus and nucleolus.
Alternative names
E2IG3, NS, GNL3, Guanine nucleotide-binding protein-like 3, E2-induced gene 3 protein, Novel nucleolar protein 47, Nucleolar GTP-binding protein 3, Nucleostemin, NNP47