GNLY
Function
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Post-translational modifications
A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
Tissue Specificity
Expressed in natural killer and T-cells.
Cellular localization
- Secreted
- Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
Alternative names
LAG2, NKG5, TLA519, GNLY, Granulysin, Lymphokine LAG-2, Protein NKG5, T-cell activation protein 519