GNPDA2

Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling.

Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.

Ubiquitous, with highest expression detected in testis, ovary, placenta, and heart.

• Cytoplasm

GNP2, GNPDA2, Glucosamine-6-phosphate isomerase 2, Glucosamine-6-phosphate deaminase 2, Glucosamine-6-phosphate isomerase SB52, GNPDA 2, GlcN6P deaminase 2

• entrezGene:132789
• omim:613222
• swissprot:Q8TDQ7

Proteins

31085Da