GOLM1
Function
Unknown. Cellular response protein to viral infection.
Post-translational modifications
Glycosylated.
Phosphorylation sites are present in the extracellular medium.
Sequence Similarities
Belongs to the GOLM family.
Tissue Specificity
Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.
Cellular localization
- Golgi apparatus
- cis-Golgi network membrane
- Single-pass type II membrane protein
- Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
Alternative names
C9orf155, GOLPH2, PSEC0242, UNQ686/PRO1326, GOLM1, Golgi membrane protein 1, Golgi membrane protein GP73, Golgi phosphoprotein 2