GOSR1/GS28

Function

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

Sequence similarities

Belongs to the GOSR1 family.

Cellular localization

• Golgi apparatus membrane
• Single-pass type IV membrane protein
• Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius).

Alternative names

• Golgi SNAP receptor complex member 1
• 28 kDa Golgi SNARE protein
• 28 kDa cis-Golgi SNARE p28
• GOS-28
• GOSR1
• GS28

Database links

• entrezGene:9527
• omim:604026
• swissprot:O95249

Target type

Proteins

Molecular weight

28613Da