GP

Glycoprotein N

Plays a role in virion attachment to host receptor (PubMed:38182887). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (PubMed:19088291) Glycoprotein N probably locks the Gn-Gc complex in a prefusion state (PubMed:34793197).

Glycoprotein C

Binds to host cell surface receptor LDLR and mediates fusion between viral and cellular membranes (PubMed:38182887). Attachment to receptor induces virion internalization predominantly through clathrin-dependent endocytosis (PubMed:19088291). Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (PubMed:34793197, PubMed:35234630). Exposure of the glycoprotein spikes to potassium is necessary for the conformational change leading to fusion (By similarity).

Envelopment polyprotein

Specific enzymatic cleavage by host MBTPS1/S1P/SKI-1 endopeptidase yield glycoprotein N (PubMed:12885882, PubMed:17898072, PubMed:25933376). Specific enzymatic cleavages by host furin-like protease and MBTPS1/S1P endopeptidase yield GP38 (PubMed:25933376).

Glycoprotein N

Glycosylated.

Glycoprotein C

Glycosylated.

Belongs to the nairovirus envelope glycoprotein family.

• Envelopment polyprotein
• Host endoplasmic reticulum membrane
• Glycoprotein N
• Virion membrane
• Multi-pass membrane protein
• Host Golgi apparatus membrane
• Multi-pass membrane protein
• Glycoprotein C
• Virion membrane
• Single-pass type I membrane protein
• Host Golgi apparatus membrane
• Single-pass type I membrane protein
• Host endoplasmic reticulum membrane
• Single-pass type I membrane protein
• Interaction between glycoprotein C and glycoprotein N is essential for proper targeting of glycoprotein C to the Golgi complex, where virion budding occurs.
• Non-Structural protein M
• Host Golgi apparatus membrane
• Multi-pass membrane protein

Envelopment polyprotein, M polyprotein, GP

• swissprot:Q8JSZ3

Proteins

Immunology & Infectious Disease

186589Da