Gp6
Developmental stage
Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn.
Function
Collagen receptor involved in collagen-induced platelet adhesion and activation (PubMed:16139873, PubMed:24368846). Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Tissue Specificity
Megakaryocytes and platelets.
Cellular localization
- Cell membrane
- Single-pass membrane protein
Alternative names
Platelet glycoprotein VI, GPVI, Glycoprotein 5, Gp6