GP6
Function
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Involvement in disease
Bleeding disorder, platelet-type, 11
BDPLT11
A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
Tissue Specificity
Megakaryocytes and platelets.
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass membrane protein
- Isoform 2
- Cell membrane
- Single-pass membrane protein
Alternative names
Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6