GP9
Function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Involvement in disease
Bernard-Soulier syndrome
BSS
A coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption.
None
The disease is caused by variants affecting the gene represented in this entry.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD42a, Platelet glycoprotein IX, GP-IX, GPIX, Glycoprotein 9, GP9