GPAT3
Domain
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Function
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318).
Pathway
Glycerolipid metabolism; triacylglycerol biosynthesis.
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
Sequence Similarities
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Tissue Specificity
Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
AGPAT9, MAG1, HMFN0839, UNQ2753/PRO6492, GPAT3, Glycerol-3-phosphate acyltransferase 3, GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, Acyl-CoA:glycerol-3-phosphate acyltransferase 3, Lung cancer metastasis-associated protein 1, Lysophosphatidic acid acyltransferase theta, MAG-1, AGPAT 10, 1-AGP acyltransferase 9, 1-AGPAT 9, hGPAT3, LPAAT-theta