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Glypican 4

Function

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).

Involvement in disease

Keipert syndrome

KPTS

An X-linked recessive syndrome characterized by craniofacial and digital abnormalities. Clinical features include a prominent forehead, a flat midface, hypertelorism, a broad nose, downturned corners of mouth, and widening of all distal phalanges. Additional variable features are cognitive impairment and sensorineural deafness.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the glypican family.

Cellular localization

  • Cell membrane
  • Lipid-anchor
  • GPI-anchor
  • Extracellular side
  • Secreted glypican-4
  • Secreted
  • Extracellular space

Alternative names

  • Glypican-4
  • K-glypican
  • UNQ474/PRO937
  • GPC4

Target type

Proteins

Molecular weight

62412Da