GPHA2
Function
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).
Post-translational modifications
Glycosylated.
Sequence Similarities
Belongs to the glycoprotein hormones subunit alpha family.
Tissue Specificity
Found in a variety of tissues.
Cellular localization
- Secreted
Alternative names
GPA2, ZSIG51, GPHA2, Glycoprotein hormone alpha-2, Putative secreted protein Zsig51, Thyrostimulin subunit alpha