Gpi
Function
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:2344351, PubMed:7277315, PubMed:8417789). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (By similarity). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:3352745, PubMed:3764429). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:3352745).
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Post-translational modifications
ISGylated.
Sequence Similarities
Belongs to the GPI family.
Cellular localization
- Cytoplasm
- Secreted
Alternative names
Gpi1, Gpi, Glucose-6-phosphate isomerase, GPI, Autocrine motility factor, Neuroleukin, Phosphoglucose isomerase, Phosphohexose isomerase, AMF, NLK, PGI, PHI