GPM6B
Function
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
Sequence Similarities
Belongs to the myelin proteolipid protein family.
Tissue Specificity
Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Colocalizes with SERT at the plasma membrane.
Alternative names
M6B, GPM6B, Neuronal membrane glycoprotein M6-b, M6b