GPN1
Function
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).
Sequence Similarities
Belongs to the GPN-loop GTPase family.
Tissue Specificity
Expressed ubiquitously.
Cellular localization
- Cytoplasm
- Nucleus
- Shuttles between the nucleus and the cytoplasm.
Alternative names
MBDIN, RPAP4, XAB1, HUSSY-23, GPN1, GPN-loop GTPase 1, MBD2-interacting protein, RNAPII-associated protein 4, XPA-binding protein 1, MBDin