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GPR132

OverviewProducts

Function

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein
  • Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity).

Alternative names

  • Probable G-protein coupled receptor 132
  • G2 accumulation protein
  • G2A
  • GPR132

Database links

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

42499Da