GPR137B
Function
Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939).
Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).
Sequence Similarities
Belongs to the GPR137 family.
Tissue Specificity
Expressed in kidney, heart, brain and placenta.
Cellular localization
- Lysosome membrane
- Multi-pass membrane protein
- Colocalized with MTOR in lysosome after amino acid stimulation.
Alternative names
TM7SF1, GPR137B, Integral membrane protein GPR137B, Transmembrane 7 superfamily member 1 protein