GPR161
Function
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Involvement in disease
Medulloblastoma
MDB
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
None
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
- Cell projection
- Cilium membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
- Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).
Alternative names
G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161