GPR62
Domain
Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.
Function
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Endosome membrane
- Multi-pass membrane protein
- Colocalizes with ARRB2 in the endosome (PubMed:28827538).
Alternative names
G-protein coupled receptor 62, G-protein coupled receptor GPCR8, G-protein coupled receptor KPG_005, hGPCR8, GPR62