GPR65

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).

Belongs to the G-protein coupled receptor 1 family.

Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.

• Cell membrane
• Multi-pass membrane protein

TDAG8, GPR65, Psychosine receptor, G-protein coupled receptor 65, T-cell death-associated gene 8 protein

• entrezGene:8477
• omim:604620
• swissprot:Q8IYL9

Proteins

Immuno-oncology

39333Da