GPR78
Function
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
UNQ5925/PRO19818, GPR78, G-protein coupled receptor 78