GPR83
Function
G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus.
Alternative names
GPR72, JP05, KIAA1540, GPR83, G-protein coupled receptor 83, G-protein coupled receptor 72