GPR88
Function
Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473).
Involvement in disease
Chorea, childhood-onset, with psychomotor retardation
COCPMR
An autosomal recessive neurodevelopmental disorder characterized by abnormal involuntary movements, marked speech delay, intellectual disability and learning difficulties.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expressed predominantly in the striatum.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell projection
- Cilium membrane
- Multi-pass membrane protein
- Cytoplasm
- Nucleus
- Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (PubMed:23936473). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood.
Alternative names
STRG, GPR88, G protein-coupled receptor 88, Striatum-specific G-protein coupled receptor