Glutathione Peroxidase 1

Function

Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism (PubMed:11115402).

Post-translational modifications

During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.

Sequence similarities

Belongs to the glutathione peroxidase family.

Tissue specificity

Expressed in platelets (at protein level).

Cellular localization

• Cytoplasm

Alternative names

• Glutathione peroxidase 1
• GPx-1
• GSHPx-1
• Cellular glutathione peroxidase
• GPX1

Database links

• entrezGene:2876
• omim:138320
• swissprot:P07203

Target type

Proteins

Molecular weight

22088Da