PRDC

Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.

Tooth agenesis, selective, 9

STHAG9

A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG9 inheritance is autosomal dominant.

None

The disease is caused by variants affecting the gene represented in this entry.

N-glycosylated.

Belongs to the DAN family.

• Secreted

CKTSF1B2, DAND3, PRDC, GREM2, Gremlin-2, DAN domain family member 3, Protein related to DAN and cerberus

• entrezGene:64388
• omim:608832
• swissprot:Q9H772

Proteins

Oncology

19320Da