GRIA1 phospho S836

Domain

The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Post-translational modifications

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).

Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.

Tissue specificity

Widely expressed in brain.

Cellular localization

• Cell membrane
• Multi-pass membrane protein
• Endoplasmic reticulum membrane
• Multi-pass membrane protein
• Cell junction
• Synapse
• Postsynaptic cell membrane
• Multi-pass membrane protein
• Cell junction
• Synapse
• Postsynaptic density membrane
• Multi-pass membrane protein
• Cell projection
• Dendrite
• Cell projection
• Dendritic spine
• Early endosome membrane
• Multi-pass membrane protein
• Recycling endosome membrane
• Multi-pass membrane protein
• Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity).

Alternative names

• Glutamate receptor 1
• GluR-1
• AMPA-selective glutamate receptor 1
• GluR-A
• GluR-K1
• GluA1
• GRIA1
• GLUH1
• GLUR1

Database links

• swissprot:P42261

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

101506Da