Glutamate receptor 3/GluA3

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (PubMed:17989220). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17989220). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (PubMed:21172611).

Intellectual developmental disorder, X-linked, syndromic, Wu type

MRXSW

A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSW patients have moderate intellectual disability, and additional variable features such as macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia.

None

The disease is caused by variants affecting the gene represented in this entry.

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.

• Cell membrane
• Multi-pass membrane protein
• Postsynaptic cell membrane
• Multi-pass membrane protein
• Postsynaptic density membrane

GluA3, GLUR3, GLURC, GRIA3, Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3

• entrezGene:2892
• omim:305915
• swissprot:P42263

Proteins

Neuroscience

101157Da