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GRIK3/GluK3
Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.
Sequence similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- Synapse
- Postsynaptic cell membrane
- Multi-pass membrane protein
Alternative names
- GluK3
- Excitatory amino acid receptor 5
- Glutamate receptor 7
- EAA5
- GluR-7
- GluR7
- GRIK3
- GLUR7
Database links
Target type
Proteins
Molecular weight
104037Da