GRIK5
Function
Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1 and GRIK2 subunits (PubMed:1321949, PubMed:14511640, PubMed:8730589). Can form functional heteromeric receptors with GRIK3 (By similarity).
Sequence Similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Postsynaptic cell membrane
- Multi-pass membrane protein
- Presynaptic cell membrane
- Multi-pass membrane protein
- Association with GRIK2 is required for its cell membrane localization and channel activity.
Alternative names
GRIK2, GRIK5, GluK5, Excitatory amino acid receptor 2, Glutamate receptor KA-2, EAA2, KA2