GRIPAP1
Function
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).
GRASP-1 C-terminal chain
Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
Post-translational modifications
Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.
Cellular localization
- Early endosome membrane
- Peripheral membrane protein
- Recycling endosome membrane
- Peripheral membrane protein
- Cell projection
- Axon
- Cell projection
- Dendrite
- Synapse
- Localizes to recycling endosomal tubules that are emanating from early endosomes.
Alternative names
KIAA1167, GRIPAP1, GRIP1-associated protein 1, GRASP-1