GRK6
Function
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Post-translational modifications
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Tissue Specificity
Widely expressed.
Cellular localization
- Membrane
- Lipid-anchor
Alternative names
GPRK6, GRK6, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6