GRK7
Function
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Post-translational modifications
Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Tissue Specificity
Retinal cones, outer and inner segments.
Cellular localization
- Membrane
- Lipid-anchor
Alternative names
GPRK7, GRK7, Rhodopsin kinase GRK7, G protein-coupled receptor kinase 7, G protein-coupled receptor kinase GRK7