GRM2
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Sequence Similarities
Belongs to the G-protein coupled receptor 3 family.
Tissue Specificity
Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Synapse
- Cell projection
- Dendrite
Alternative names
GPRC1B, MGLUR2, GRM2, Metabotropic glutamate receptor 2, mGluR2