GRM3
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Sequence Similarities
Belongs to the G-protein coupled receptor 3 family.
Tissue Specificity
Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPRC1C, MGLUR3, GRM3, Metabotropic glutamate receptor 3, mGluR3