Metabotropic Glutamate Receptor 3/MGLUR3

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Tissue specificity

Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

• Metabotropic glutamate receptor 3
• mGluR3
• MGLUR3
• GRM3
• GPRC1C

Database links

• entrezGene:2913
• omim:601115
• swissprot:Q14832

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

98879Da