Metabotropic Glutamate Receptor 3/MGLUR3

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Belongs to the G-protein coupled receptor 3 family.

Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.

• Cell membrane
• Multi-pass membrane protein

GPRC1C, MGLUR3, GRM3, Metabotropic glutamate receptor 3, mGluR3

• entrezGene:2913
• omim:601115
• swissprot:Q14832

Proteins

Neuroscience

98879Da