GRM4
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Sequence Similarities
Belongs to the G-protein coupled receptor 3 family.
Tissue Specificity
Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPRC1D, MGLUR4, GRM4, Metabotropic glutamate receptor 4, mGluR4