Products
Proteins and Peptides
Proteins and peptidesAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsFeatured product
Step up your high-throughput screening with our 384-well SimpleStep ELISA kits.
Learn more about all our product ranges with our product overviews.
Resources
Featured events
Make new connections at our global events.
Support
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Metabotropic Glutamate Receptor 5
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Sequence similarities
Belongs to the G-protein coupled receptor 3 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
- Metabotropic glutamate receptor 5
- mGluR5
- MGLUR5
- GPRC1E
- GRM5
Database links
Target type
Proteins
Primary research area
Neuroscience
Molecular weight
132469Da