Metabotropic Glutamate Receptor 5

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

Belongs to the G-protein coupled receptor 3 family.

• Cell membrane
• Multi-pass membrane protein

GPRC1E, MGLUR5, GRM5, Metabotropic glutamate receptor 5, mGluR5

• entrezGene:2915
• omim:604102
• swissprot:P41594

Proteins

Neuroscience

132469Da