MGLUR8

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Belongs to the G-protein coupled receptor 3 family.

• Cell membrane
• Multi-pass membrane protein

GPRC1H, MGLUR8, GRM8, Metabotropic glutamate receptor 8, mGluR8

• entrezGene:2918
• omim:601116
• swissprot:O00222

Proteins

Neuroscience

101741Da