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MGLUR8

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • Metabotropic glutamate receptor 8
  • mGluR8
  • GRM8
  • GPRC1H
  • MGLUR8

Target type

Proteins

Molecular weight

101741Da