GRM8
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Sequence Similarities
Belongs to the G-protein coupled receptor 3 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPRC1H, MGLUR8, GRM8, Metabotropic glutamate receptor 8, mGluR8