Growth factor receptor-bound protein 14
Domain
The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3.
Function
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Post-translational modifications
Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2.
Sequence Similarities
Belongs to the GRB7/10/14 family.
Tissue Specificity
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Endosome membrane
- Peripheral membrane protein
- Upon insulin stimulation, translocates to the plasma membrane.
Alternative names
Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14