Growth hormone secretagogue receptor type 1
Function
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
Involvement in disease
Growth hormone deficiency, isolated partial
GHDP
A disorder characterized by partial growth hormone deficiency resulting in growth delay and short stature, sometimes associated with recurrent episodes of abdominal pain, vomiting, ketosis and hypoglycemia.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Pituitary and hypothalamus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, Ghrelin receptor, GHRP, GHSR