GSR
Domain
Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface.
Function
Maintains high levels of reduced glutathione in the cytosol.
Involvement in disease
Hemolytic anemia due to glutathione reductase deficiency
HAGRD
An autosomal recessive disease characterized by hemolytic anemia and impaired activity of glutathione reductase. Patients experience hemolytic anemia in response to oxidative stress or ingestion of fava beans.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Cellular localization
- Isoform Mitochondrial
- Mitochondrion
- Isoform Cytoplasmic
- Cytoplasm
Alternative names
GLUR, GRD1, GSR, GR, GRase