GSTA3
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).
Sequence Similarities
Belongs to the GST superfamily. Alpha family.
Cellular localization
- Cytoplasm
Alternative names
Glutathione S-transferase A3, GST class-alpha member 3, Glutathione S-transferase A3-3, GSTA3