GSTO1
Function
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Sequence Similarities
Belongs to the GST superfamily. Omega family.
Tissue Specificity
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
GSTTLP28, GSTO1, Glutathione S-transferase omega-1, GSTO-1, Glutathione S-transferase omega 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, S-(Phenacyl)glutathione reductase, GSTO 1-1, MMA(V) reductase, SPG-R