GSTP1
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Sequence Similarities
Belongs to the GST superfamily. Pi family.
Cellular localization
- Cytoplasm
- Mitochondrion
- Nucleus
- The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.
Alternative names
FAEES3, GST3, GSTP1, Glutathione S-transferase P, GST class-pi, GSTP1-1