GST3 / GST pi

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Belongs to the GST superfamily. Pi family.

• Cytoplasm
• Mitochondrion
• Nucleus
• The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

FAEES3, GST3, GSTP1, Glutathione S-transferase P, GST class-pi, GSTP1-1

• entrezGene:2950
• omim:134660
• swissprot:P09211

Proteins

Metabolism

23356Da