GTF2E1

Function

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Sequence Similarities

Belongs to the TFIIE alpha subunit family.

Cellular localization

• Nucleus

Alternative names

TF2E1, GTF2E1, General transcription factor IIE subunit 1, General transcription factor IIE 56 kDa subunit, Transcription initiation factor IIE subunit alpha, TFIIE-alpha

Database links

swissprot:P29083 omim:189962 omim:189964 entrezGene:2961 entrezGene:2960 swissprot:P29084