GTF2F1

Function

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

Post-translational modifications

Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.

Sequence Similarities

Belongs to the TFIIF alpha subunit family.

Cellular localization

• Nucleus

Alternative names

RAP74, GTF2F1, General transcription factor IIF subunit 1, General transcription factor IIF 74 kDa subunit, Transcription initiation factor IIF subunit alpha, Transcription initiation factor RAP74, TFIIF-alpha

Database links

swissprot:P35269 omim:189968 entrezGene:2963 entrezGene:2962 swissprot:P13984 omim:189969