GTF2H1

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

Belongs to the TFB1 family.

• Nucleus

BTF2, GTF2H1, General transcription factor IIH subunit 1, Basic transcription factor 2 62 kDa subunit, General transcription factor IIH polypeptide 1, TFIIH basal transcription factor complex p62 subunit, BTF2 p62

• entrezGene:2965
• omim:189972
• swissprot:P32780

Proteins

Epigenetics

62032Da