Guanine nucleotide-binding protein G(t) subunit alpha-2
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Sequence Similarities
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Tissue Specificity
Retinal rod outer segment.
Cellular localization
- Cell projection
- Cilium
- Photoreceptor outer segment
- Photoreceptor inner segment
- Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light.
Alternative names
Guanine nucleotide-binding protein G(t) subunit alpha-2, Transducin alpha-2 chain, GNAT2