Guanine nucleotide exchange factor VAV2 phospho Y172
Function
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Post-translational modifications
Phosphorylated on tyrosine residues in response to FGR activation.
Tissue Specificity
Widely expressed.
Alternative names
Guanine nucleotide exchange factor VAV2, VAV-2, VAV2