GUCY1A2
Function
Has guanylyl cyclase on binding to the beta-1 subunit.
Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
Sequence Similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Tissue Specificity
Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium.
Cellular localization
- Cytoplasm
Alternative names
GUC1A2, GUCSA2, GUCY1A2, Guanylate cyclase soluble subunit alpha-2, GCS-alpha-2